rs11209032
A SNP in the IL23R gene on chromosome 1. Its most notable genotype is A;A: 1.3x higher risk for spondylitis
- Gene
- IL23R
- Location
- Chr 167,274,409 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 32%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBad1.3x higher risk for spondylitis
- A;GBad1.3x higher risk for spondylitis
- G;GGoodnormal risk
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 13% A;G 43% G;G 44%
- European ancestry (Utah)A;A 10% A;G 41% G;G 49%
- Han Chinese (Beijing)A;A 23% A;G 54% G;G 23%
- Japanese (Tokyo)A;A 19% A;G 47% G;G 35%
- Yoruba (Nigeria)A;A 7% A;G 32% G;G 61%
- African ancestry (Southwest US)A;A 5% A;G 37% G;G 58%
- Chinese (Denver)A;A 24% A;G 55% G;G 21%
- Gujarati IndianA;A 29% A;G 49% G;G 23%
- Luhya (Kenya)A;A 5% A;G 34% G;G 62%
- Mexican ancestry (Los Angeles)A;A 4% A;G 35% G;G 61%
- Maasai (Kenya)A;A 10% A;G 42% G;G 49%
- TuscanA;A 8% A;G 53% G;G 39%
Related
Conditions, medicines and genes
Other IL23R SNPs
- rs11209026A;A0.26x lower risk for certain autoimmune diseases.Important
- rs2201841T;TNo summary available.Worth knowing
- rs7530511T;T9x increased risk for Graves diseaseWorth knowing
- rs10889677A;C1.5x increased risk for certain autoimmune diseases; 2x increased risk for Graves diseaseWorth knowing
- rs11465770C;Tpossibly lower risk of Crohn's Disease (OR=0.30)Minor
- rs11465804G;G0.68x lower risk for spondylitisMinor
- rs1004819G;G1.5x risk of Crohn's disease, 1.2 for developing ankylosing spondylitisMinor
- rs1343151G;Gnormal riskTypical
Notes
From SNPedia
Notes
rs11209032 is one of several SNPs in the IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 1.3 (p=7.5x10e-9).PMID 17952073, PMID 18037607 rs11209032 and rs1495965 no significant association with systemic sclerosis
Source and license
Adapted from rs11209032 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.