rs7517847

the association may be specific to Crohn's disease, as opposed to all types of IBD. significant associations with rs1004819, rs7517847, and rs11209026. Having any CARD15 variant was associated with a significant risk for Crohn's disease (P < 0.0001). rs7517847 (P=4.9x10(-9), OR 0.65, 0.56-0.75), is statistically independent of rs11209026. Replicated reduced risk for Crohn's disease with the rs7517847(G) allele in a study of Italian patients, but not ulcerative colitis. Each incidence of the G allele was associated with a decrease in Crohn's Disease in New Zealand populations studied. Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort. rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants. Association analysis of IL-12B and IL-23R polymorphisms in myocardial infarction. Fine mapping versus replication in whole-genome association studies. CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population. IL23R: a susceptibility locus for celiac disease and multiple sclerosis? IL23R and IL12B polymorphisms in Spanish IBD patients: no evidence of interaction. IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease. No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus. Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions. Variants of the IL23R gene are associated with ankylosing spondylitis but not with Sjogren syndrome in Hungarian population samples. Interleukin-23 receptor gene variants in Hungarian systemic lupus erythematosus patients. Polymorphisms of IL23R and Vogt-Koyanagi-Harada syndrome in a Chinese Han population. Association of the interleukin-23 receptor gene variant rs11209026 with Crohn's disease in German children. Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset. An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians.